Long‐Chain Lipids Are Required for the Innate Immune Recognition of Trehalose Diesters by Macrophages

Abstract

Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO and cytokine production by macrophages. In this work, we show that longer lipids (C(20) -C(26)) are required for macrophage activation, with C(22) giving optimal activity.