Concepedia

Preparation of Aryloxetanes and Arylazetidines by Use of an Alkyl−Aryl Suzuki Coupling

Matthew A. J. Duncton, M. Angels Estiarte, Darlene Q. Tan, Carl Kaub, Donogh J. R. O’Mahony, Russell J. Johnson, Matthew Cox, William T. Edwards, Min Wan, John Kincaid,

Organic Letters · 2008 · 81 citations · 16 references

DOI

Concepts

Abstract

The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki coupling, is presented.

References

16

Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides

Jianrong Steve Zhou, Gregory C. Fu · Journal of the American Chemical Society · 2004 · 325 citations

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Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids

Francisco González‐Bobes, Gregory C. Fu · Journal of the American Chemical Society · 2006 · 287 citations

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Alkyl−Alkyl Suzuki Cross-Couplings of Unactivated Secondary Alkyl Halides at Room Temperature

Bunnai Saito, Gregory C. Fu · Journal of the American Chemical Society · 2007 · 261 citations · Full text

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Oxetanes as Promising Modules in Drug Discovery

Georg Wuitschik, Mark Rogers‐Evans, Klaus Müller et al. · Angewandte Chemie International Edition · 2006 · 257 citations

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Amino Alcohols as Ligands for Nickel‐Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides with Arylboronic Acids.

Francisco González‐Bobes, Gregory C. Fu · ChemInform · 2006 · 236 citations · Full text

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