IL‐18 serum level and IL‐18 promoter gene polymorphism in Iranian patients with gastrointestinal cancers

Abstract

Results of this investigation suggests that Single Nucleotide Polymorphism (SNP) at position -137 G/C and haplotype frequency may play a role in predisposition of Iranian patients to stomach and colorectal cancers. In addition, increasing serum IL-18 level may have clinical importance as a diagnostic marker in patients with stomach and colorectal cancer.