Repolarization Abnormalities, Arrhythmia and Sudden Death in Canine Tachycardia-Induced Cardiomyopathy

Abstract

Tachycardia-induced HF exhibits malignant arrhythmia and SCD, along with prolonged, heterogeneous repolarization and heightened sensitivity to CsCl at chamber and cellular levels. Thus, it appears to be a useful model for studying mechanisms and therapy of SCD in HF.