Racemisation during peptide synthesis with 1‐alkynylamines (ynamines)

A. S. van Mourik, E. Harryvan, J. F. Arens

Recueil des Travaux Chimiques des Pays-Bas · 1965 · 13 citations · 3 references

Concepts

Abstract

Abstract The Anderson‐Young test was applied to peptide syntheses in which 1‐dialkylamino‐1‐alkynes (ynamines) were used as condensing agents. Considerable racemisation was observed. PHT‐ L ‐phe anhydride could be obtained from PHT‐ L ‐phe and 1‐diethylamino‐1‐pentyne without racemisation, provided that no excess of reagent was used.

References

3