Diels−Alder Cycloaddition Approach to Puupehenone-Related Metabolites: Synthesis of the Potent Angiogenesis Inhibitor 8-Epipuupehedione

Abstract

A new synthetic strategy toward puupehenone-related bioactive metabolites from sclareol oxide, based on a Diels-Alder cycloaddition approach, is described. Utilizing this, marine ent-chromazonarol and the potent angiogenesis inhibitor 8-epipuupehedione have been synthesized.