Hypogammaglobulinemia in Steroid-Dependent Asthmatics Correlates with the Daily Dose of Oral Prednisolone

Abstract

Oral PSL can potentially suppress humoral immunity in severe asthma. In asthmatics, hypogammaglobulinemia could develop in those on a daily dose of PSL >12.5 mg, but is independent of the duration of such treatment. No suppression of humoral immunity was noted on inhaled corticosteroid therapy alone, either at low or high dose.