European Journal of Immunology · 2010 · 231 citations · 50 references
Veterinary MedicineImmunologyInfectious DiseasesImmunology Of Infectious DiseasesImmunopathologyInflammationCell-mediated ImmunityCytokine BiologyImmune RegulationImmune ResponseImmune Responses To InfectionImmunopathology Of Infectious DiseasesEnhanced ProtectionImmune Response To Bacterial InfectionLung Immune ResponseMycobacterium Tuberculosis InfectionPathogen ClearanceTh1 Immune ResponseTh1 ResponsesTh17 Responses
IL‑10 modulates the immune response to balance pathogen clearance with immunopathology. IL‑10‑deficient mice infected with Mtb exhibit accelerated IFN‑γ‑driven Th1 responses, increased CD4⁺ T‑cell infiltration, and heightened chemokine/cytokine production, leading to lower lung bacterial loads and, when IL‑17 is neutralized, reduced splenic dissemination.
IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(-/-) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN-γ response in the lung, an increased influx of CD4(+) T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL-17, in both the lung and the serum. Neutralization of IL-17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN-γ-producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb.
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Peng Ye, Fred H. Rodriguez, Suzanne T. Kanaly et al. · The Journal of Experimental Medicine · 2001 · 1.5K citations · Full text