Journal of Labelled Compounds and Radiopharmaceuticals · 1986 · 16 citations · 3 references
Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryHeterocyclicDrug Metabolism StudiesNew Hypnotic AgentMedicineNatural SciencesOrganic ChemistryPharmacotherapyChemistrySynthesis MethodPharmacologySpecific RadioactivityAnesthesiologyNatural Product Synthesis
Abstract The synthesis of [ 14 C]Zolpidem, a new hypnotic agent having a non‐benzodiazepine structure, is described. This compound was synthesised in a 64% overall radio‐chemical yield from potassium[ 14 C]cyanide and with a specific radioactivity of 56 mCi/mmol. It was used for pharmacokinetic and drug metabolism studies.
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