Bovine respiratory syncytial virus-specific IgE is associated with interleukin-2 and -4, and interferon-γ expression in pulmonary lymph of experimentally infected calves

Abstract

Infection with BRSV was associated with production of BRSV-specific IgE, and IL-4 message was commonly found in lymph cells of infected calves. This finding supports the concept that BRSV-induced pathophysiology involves a T helper cell type-2 response. Effective therapeutic and prophylactic strategies could, therefore, be developed using immunomodulation to shift the immune response more toward a T helper cell type-1 response.