Modulating Aβ_33–42 Peptide Assembly by Graphene Oxide

Abstract

Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (Aβ33-42 ). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene-based materials to inhibit amyloidosis.