DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility. - Concepedia

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DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility.

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References

1999

Year

SIMONE S. JEAN, E. Quelvennec, Mehdi Alizadeh, Pascal Guggenbuhl, Brigitte Birebent, Aleth Perdriger, B. Grosbois, P Y Pawlotsky, G. Sémana

Abstract

This study confirmed the role of the MHC region in the susceptibility to Sjögren's disease, and for the first time suggests a synergistic interaction between two HLA-DRB1 extended haplotypes in the genetic mechanisms controlling the disease.