The Relative Radiosensitivity of Rat Lenses as a Function of Age

Abstract

The effect of age on the development of radiation cataracts in rat lenses has been investigated using the Columbia-Sherman rat as an experiment model. A detailed pattern of age dependence was obtained at several different dose levels. In general, at dose levels from 200 to 300 rads the lens changes occurred sooner and progressed faster in the adult lenses than in young lenses. In the dose range from 300 rads to 900 rads opacities developed sooner in the young lenses but progression was faster and severe opacities developed sooner in adult lenses. Above 900 rads opacities developed sooner and progressed faster in the young lenses.