Single-Dose Azithromycin versus Penicillin G Benzathine for the Treatment of Early Syphilis

Abstract

Single-dose oral azithromycin is effective in treating syphilis and may be particularly useful in developing countries in which the use of penicillin G benzathine injections is problematic. However, recent reports of azithromycin-resistant Treponema pallidum in the United States indicate the importance of continued monitoring for resistance.