Concepedia

Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo

Takayuki Yonezawa, Shin‐ichi Hasegawa, Midori Asai, Tadashi Ninomiya, Toshinori Sasaki, Byung‐Yoon Cha, Toshiaki Teruya, Hidehiro Ozawa, Kazumi Yagasaki, Kazuo Nagai,

European Journal of Pharmacology · 2010 · 57 citations · 17 references

Concepts

MedicineMedicinal ChemistryPharmacologyBiochemical PharmacologyBone MetabolismMolecular PharmacologyBone HealthBone Metabolism PharmacotherapyOsteoclast BiologyOsteoclast FunctionOsteogenesisOsteoporosisAnti-resorptive TherapyBone Resorption InhibitionNf-κb SignalingOsteoclast InhibitionOsteoclast Metabolism

References

17

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Hiroshi Takayanagi, Sunhwa Kim, Takako Koga et al. · Developmental Cell · 2002 · 2.7K citations · Full text

Medicine, Cell Biology, Molecular Biology +16

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott et al. · Biochemical Journal · 2007 · 2.5K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

Q.W. Xie, Yumiko Kashiwabara, Carl Nathan · Journal of Biological Chemistry · 1994 · 2.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +14

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Joseph R. Arron, Monte M. Winslow, Alberto Polleri et al. · Nature · 2006 · 698 citations

Life Sciences, Genetics, Molecular Genetics +11

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

Toshio Suda · Endocrine Reviews · 1999 · 481 citations

Life Sciences, Cell Biology, Immunology +17