Asymmetric Synthesis of α‐Alkyl‐α‐aminocarboxylic Acids by Alkylation of 1‐<i>chiral</i>‐Substituted 2‐Imidazolin‐5‐ones

Abstract

Over 95% asymmetric induction is achieved, given favorable substituent combinations, in the key step of a new synthesis of α‐alkyl α‐amino acids (1) , X=H. Chemical yields are good, and the chiral auxiliary agent can be recovered. equation image