Clinical and Molecular Markers of Chronic Interstitial Nephropathy in Congenital Unilateral Ureteropelvic Junction Obstruction

Abstract

In congenital unilateral ureteropelvic junction obstruction chronic interstitial nephropathy and poor postoperative recovery seem to be associated with an earlier diagnosis of hydronephrosis, functional loss greater than 10% and worse scintigraphic drainage. Moreover, there is a strong correlation between molecular fibrogenic markers and histologically and scintigraphically demonstrated renal damage.