Single Dose Imipramine Reduces Nocturnal Urine Output in Patients With Nocturnal Enuresis and Nocturnal Polyuria

Abstract

Imipramine has a vasopressin independent antidiuretic effect if nocturnal polyuria is present. The antidiuretic effect of imipramine can be attributed primarily to increased alpha-adrenergic stimulation in the proximal tubules with a secondary increased urea and water reabsorption more distally in the nephron.