EXPERIMENTAL STUDY ON CROSS-CONTACT ALLERGY DUE TO DITHIOCARBAMATE FUNGICIDES

Abstract

Cross sensitizations among dithiocarbamate fungicides were investigated using the guinea pig maximization test. Extreme potency of cross-reaction was noted among ethylene bis-dithiocarbamates, maneb, mancozeb and zineb. Such degree of potentialities, however, was not revealed in cases of dimethyldithiocarbamates, ferbam, thiram, ziram and dimethyldithiocarbamic acid sodium salt. Cross-contact allergy among other combinations of dithiocarbamates and their related compounds were tested and discussed.