In Vivo Fluorescence Imaging with Ag₂S Quantum Dots in the Second Near‐Infrared Region

Abstract

Hits the dot: Ag2S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating (see scheme) were synthesized for in vivo small-animal imaging. The 6PEG-Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag2S QDs occurs mainly through the biliary pathway in mice. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.