Nucleic Acids Research · 1977 · 341 citations · 7 references
Life SciencesGeneticsMolecular BiologyGenomicsMolecular EvolutionSequence AnalysisGenomic DivergenceNucleic Acid PurificationNucleic Acid SequencingRestriction Enzyme TechnologyAgarose Gel ElectrophoresisDna Sequence AnalysisDna Sequence CompositionGel ElectrophoresisRestriction EndonucleasesRestriction Enzyme DigestionRestriction Fragment Length Polymorphism AnalysisSequence Divergence
An estimation of the DNA sequence divergence between defined DNA secquences of individuals or species may be made from comparison by gel electrophoresis of restriction endonuclease digests. This analysis is applicable to purified DNA sequence of moderate complexity (1-100 X 10(6) daltons) which have diverged by base substitution of 0.5 to 25% of nucleotides.
7
Investigation of the organization of mammalian chromosomes at the DNA sequence level.
Winston Salser, S. L. Bowen, D.L. Browne et al. · PubMed · 1976 · 127 citations
Life Sciences, Biology, Genetics +16