Nucleosides and Nucleotides · 1999 · 13 citations · 1 references
PharmacyMolecular PharmaceuticsNuclear MedicineMolecular ImagingNucleic Acid ChemistryTherapeutic Nuclear MedicineNucleic Acid LabelingRadiopharmaceutical PreparationRadiopharmaceuticalsRibonucleic Acid (Rna) ChemistryRna ChemistryRna ModificationAptamer ChemistryAptamer-based Imaging AgentsRna AptamersTargeted Radionuclide ImagingTechnetium-99m ChemistryTechnetium-99m LabelingTechnetium-99m Radiopharmaceuticals
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90-95% radiochemical yield and specific activities of 37MBq/nmol leading to 1:1-Tc-99m-N3S-aptamers.
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Preparation and use of NHS-MAG3 for technetium-99m labeling of DNA
Paul Winnard, Fi‐John Chang, Mary Rusckowski et al. · Nuclear Medicine and Biology · 1997 · 88 citations