Concepedia

Pharmacological Modulation of Cardiac Gap Junctions to Enhance Cardiac Conduction

Benjamin C. Eloff, Eran Gilat, Xiaoping Wan, David Rosenbaum

Circulation · 2003 · 108 citations · 31 references

DOIFull text

Open access

Abstract

These data suggest that ZP123 significantly attenuates gap junction closure during acidosis. Preservation of intercellular coupling diminished CV slowing and heterogeneous repolarization, eliminating arrhythmogenic substrates.

References

31

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