AIDS · 2005 · 15 citations · 3 references
Public HealthInfectious Disease ControlPharmacotherapyHiv ControlHiv PreventionInfectious Disease PharmacotherapyAntiretroviral TherapyAntiviral TherapyMaintenance TherapyPatient AdherenceTreatment AdherenceTreatment DurationAdherenceAdherence In Hiv TreatmentHighly Active Antiretroviral TherapyHiv Antiretroviral TherapyLong-acting Antiretroviral TherapyRetention In Hiv CareTreatment Interruption DecisionsTreatment Interruption Management
The introduction of highly active antiretroviral therapy in 1995 dramatically decreased AIDS-related events and deaths rates; however, the enthusiasm among the medical and social community was soon limited by the growing incidence of various side-effects that often greatly limited patients' quality of life. The second problem caused by such a complex treatment consisted of sub-optimal adherence, with a consequent higher risk of the development of drug resistance.
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Steven G. Deeks, Terri Wrin, Teri Liegler et al. · New England Journal of Medicine · 2001 · 661 citations · Full text
Effect of prolonged discontinuation of successful antiretroviral therapy on CD4 T cells
Franco Maggiolo, Diego Ripamonti, Gianpietro Gregis et al. · AIDS · 2004 · 123 citations