Synthesis of spiro- and fused heterocycles by palladium catalysed carbo- and heteroannulation cascades of allenes

Abstract

Two novel palladium catalysed cascade processes involving the generation of a (π-allyl)palladium intermediate from allenes in an intra- or intermolecular fashion, followed by regioselective intramolecular nucleophilic addition of amines, alcohols or malonates provide spiro- or linear fused heterocycles in good yield.