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The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors

Molecular PhysiologySignal TransductionBiochemistryG Protein-coupled ReceptorFunctional SelectivityReceptor (Biochemistry)A2 Adenosine ReceptorsLoop Exchange StudyMedicineCell BiologyCell SignalingCellular PhysiologySecond Extracellular Loop