Insecticidal quinoline and isoquinoline isoxazolines

The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels

Yoshihisa Ozoe, Miho Asahi, Fumiyo Ozoe et al. · Biochemical and Biophysical Research Communications · 2009 · 284 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

Wesley L. Shoop, Eric J. Hartline, Brandon R. Gould et al. · Veterinary Parasitology · 2014 · 191 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

New GABA/Glutamate Receptor Target for [³H]Isoxazoline Insecticide

Pablo García‐Reynaga, Chunqing Zhao, Richmond Sarpong et al. · Chemical Research in Toxicology · 2013 · 88 citations

Medicine, Entomology, Pharmacology +15

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

George P. Lahm, Daniel Cordova, James D. Barry et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 79 citations

Medicine, Entomology, Pharmacology +13

Synthesis and Antitumor Activity of 4- and 5-Substituted Derivatives of Isoquinoline-1-carboxaldehyde Thiosemicarbazone

Mao‐Chin Liu, Tai‐Shun Lin, Philip G. Penketh et al. · Journal of Medicinal Chemistry · 1995 · 48 citations

Natural Sciences, Medicinal Chemistry, Pharmacology +13