Synthesis of the C20−C26 Building Block of Halichondrins via a Regiospecific and Stereoselective S_N2‘ Reaction

Abstract

[reaction: see text] A regiospecific and stereoselective S(N)2' reaction to convert the trisylate into the vinyl iodide is presented. The homoallylic alcohol is used to direct the delivery of LiCu(Me)(2).