Acute Pulmonary Disease Caused by Phenytoin

Abstract

Acute pulmonary disease may occur as part of the hypersensitivity angitis produced by phenytoin sodium. The clinical features of the pulmonary involvement are fever, dyspnea, hypoxemia, and bilateral radiographic infiltrates. The pathologic process is an interstitial pneumonitis that appears reversible with cessation of the drug and treatment with corticosteroids.