Americanolides A−C, New Guaianolide Sesquiterpenes from the Caribbean Sea Plume <i>Pseudopterogorgia americana</i>

Abstract

A chemical reinvestigation of the common sea plume Pseudopterogorgia americana from Puerto Rico has revealed for the first time the presence of a new family of sesquiterpenoid lactones possessing the guaiane skeleton. The structures of guaianolides 1−5, including relative stereochemistries, were elucidated by NMR, NOE, and MS experiments. The proposed structures were further corroborated by molecular modeling studies.