Publication | Closed Access
Polar Effects in the Transition State of the Bergman Cyclization
50
Citations
9
References
1995
Year
Bergman CyclizationHeterocyclicBiochemistryElectron Withdrawing SubstituentsIn-plane π-OrbitalsNatural SciencesOrganic ChemistryFree Activation EnergyQuantum ChemistryChemistryEnantioselective Synthesis
Abstract From the kinetic data of enediynes 1a-c it is concluded that electron withdrawing substituents are lowering the free activation energy in the Bergman cycloaromatization by decreasing the repulsion of the in-plane π-orbitals.
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