A potentiometric sensor for the determination of diclofenac

Abstract

A diclofenacselective electrode with a plasticized poly(vinyl chloride) membrane containing an ion associate of diclofenac with Astrafloxin FF as an electrode-active substance was developed. The linearity range of the electrode function varied from 5 × 10−5 to 5 × 10−2 M; the slope of the electrode function was 59.0 ± 1.2 mV/pc, and the working pH range was 9–12. The effectiveness of the use of this electrode for monitoring diclofenac in pharmaceutical preparations was demonstrated.