Invertebrate pharmacological assay of novel, potent glutamate receptor antagonists: Acylated spermines

Abstract

Abstract Synthetic analogues of arthropod polyamine‐containing toxins have been investigated for antagonism of the quisqualate‐sensitive L‐glutamate receptor (quis‐GluR) of locust muscle. Block of the cation‐selective channel gated by quis‐GluR was demonstrated for N‐(4‐hydroxyphenylpropanoyl)‐and N‐(4‐hydroxyphenylacetyl)‐spermine at significantly lower concentrations than that for spermine.