Publication | Closed Access
Synthesis of carboranes containing nucleoside bases. Unexpectedly high cytostatic and cytocidal toxicity towards cancer cells
59
Citations
5
References
1992
Year
EngineeringPathologyOrganic ChemistryPharmaceutical ChemistryMedicinal ChemistryCancer Cell BiologyAnti-cancer AgentRadiation OncologyCancer ResearchMedicineCancer TreatmentPharmacology5-Carboranyluridine 1Natural Product SynthesisBiomolecular Engineering5-Hydroxymethylcarboranyluridine 35-Carboranyldeoxyuridine 2HeterocyclicOncologyNucleoside BasesDrug Discovery
5-Carboranyluridine 1, 5-carboranyldeoxyuridine 2 and 5-hydroxymethylcarboranyluridine 3 have been prepared; they show unexpectedly high cytotoxicity towards cancer cells, with IC50 values being ca. 10–5 mol dm–3.
| Year | Citations | |
|---|---|---|
Page 1
Page 1