Agricultural and Biological Chemistry · 1984 · 43 citations · 1 references
PharmacyToxicologyAnalytical ToxicologyAquatic ToxicologyMarine ToxicologyFish ToxicologyMarine BiotoxinsNatural Toxins In FoodDinoflagellate ToxinsHydrogen Peroxide ChemistryMarine Biotoxin DetectionSaxitoxin ToxicologyShellfish BiotoxinsShellfish ToxicityToxin BiochemistryToxin Characterization
Alkaline oxidation of paralytic shellfish toxins with tert-butyl hydroperoxide yielded highly fluorescent derivatives. Even gonyautoxins I and IV and neosaxitoxin, which were nonfluorescing by previously proposed hydrogen peroxide oxidations, were successfully converted to fluorescent compounds. A continuous shellfish toxin analyzer was constructed by incorporating the reaction into a high pressure liquid chromatographic system. The limit of detection was within the range of 0.042.2 nmol for gonyautoxins I V, neosaxitoxin and saxitoxin.
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