Science · 1991 · 78 citations · 22 references
MedicineDevelopmental BiologyNeurobiologyDevelopmental NeurobiologyDevelopmental NeuroscienceEmbryologyEmbryonic Polarity EstablishmentMotor System DevelopmentNervous System DevelopmentNeural DevelopmentNeural PatterningNeural Tube DevelopmentDifferentiationEmbryonic PolarityFloor Plate DevelopmentNeural Tube EmbryologyNeural Tube MorphogenesisNeuroepithelial DifferentiationNeuroepithelial MorphogenesisNeuronal Morphogenesis
The effect of floor plate on cellular differentiation in the neural tube of quail embryos was examined. In the developing neural tube the floor plate, which consists of specialized neuroepithelial cells, is located in the ventral midline of the neural tube. When Hensen's node was extirpated the floor plate and notochord did not develop, and the normal differentiation of the ventral horn motor neurons and dorsal and ventral roots did not occur. When one side of the neural tube was deprived of notochord, the ventro-dorsal differentiation took place on both sides. However, when one side of the neural tube was deprived of the floor plate, the ventral horn motor neurons and dorsal and ventral roots did not develop on that side. These observations suggest that the floor plate influences motor neuron differentiation and acts as an intrinsic organizer to establish pattern and polarity in the developing nervous system.
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Chemotropic guidance of developing axons in the mammalian central nervous system
Marc Tessier‐Lavigne, Marysia Placzek, A.G.S. Lumsden et al. · Nature · 1988 · 690 citations
Medicine, Neurobiology, Neuroscience +14
Local application of retinoic acid to the limb bond mimics the action of the polarizing region
Cheryll Tickle, Bruce Alberts, Lewis Wolpert et al. · Nature · 1982 · 666 citations