Stereoselective Total Syntheses of Herbicidin C and Aureonuclemycin through Late‐Stage Glycosylation

Abstract

Better late than never! Two herbicidins, members of an important family of nucleoside antibiotics, have been synthesized for the first time. The route integrates a stereoselective C-glycosylation with several reagent-controlled stereoselective transformations and a surprisingly facile and highly diastereoselective late-stage N-glycosylation.