Journal of Clinical Neurophysiology · 2008 · 62 citations · 17 references
MedicineAnesthesiologyPerioperative MedicineAnesthesiaAnesthetic TechniquesPediatric AnesthesiologyAnesthesia For Spine SurgeryAnesthetic MonitoringIntraoperative Neurophysiological MonitoringPediatric AnesthesiaSpinal AnesthesiaAnesthetic Effects On Neurophysiological SignalsIntravenous Anesthetic CombinationsOrthopedic Corrective SurgeryPediatric Scoliosis SurgeryScoliosis Surgery AnesthesiaSpinal Evoked PotentialsTotal Spinal Anesthesia
Intraoperative neurophysiological monitoring (IONM) during corrective spinal surgery is widely used. Because of the possible interference with the recording of evoked potentials by inhalational anesthetics, total intravenous anesthetic (TIVA) regimens have been advocated. TIVA regimens may be difficult to use in pediatric populations due to metabolic factors. We report on the results of multimodality IONM during 18 cases in which a TIVA regimen incorporating dexmedetomidine (Precedex, Hespira, Lake Forest, IL) was used. Monitoring techniques included sensory (SSEP) and motor evoked potentials (MEP), as well as pedicle screw stimulation. SSEPs were maintained within an acceptable range of baseline amplitude (50%) and latency (10%), and MEPs remained elicitable throughout each case. We therefore found that the anesthetic regimen did not significantly interfere with any of the monitoring modalities used and conclude that IONM in the presence of dexmedetomidine is feasible under appropriate conditions.
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The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans
Thomas J. Ebert, Judith Hall, Jill A. Barney et al. · Anesthesiology · 2000 · 1.4K citations · Full text
Sedative, Amnestic, and Analgesic Properties of Small-Dose Dexmedetomidine Infusions
Judith Hall, Toni D. Uhrich, Jill A. Barney et al. · Anesthesia & Analgesia · 2000 · 1.1K citations
Effects of Intravenous Dexmedetomidine in Humans
B. C. Bloor, Denham S. Ward, Jon P. Belleville et al. · Anesthesiology · 1992 · 735 citations · Full text
Marc R. Nuwer, Edgar G. Dawson, Linda G. Carlson et al. · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · 1995 · 728 citations