A comparative evaluation of adrenalectomy and cortisone in the treatment of advanced mammary carcinoma

Abstract

Between October, 1959, and October, 1960, 39 patients with disseminated breast cancer were admitted to this study in a strictly randomized fashion. All of these patients, who ranged from 34 to 73 years of age, were at least 1 year postmenopausal-menopause having been either spontaneous or induced by surgical castration-and they had been previously treated with either androgens or estrogens for metastatic disease.