Developments for the minimally invasive treatment of tumours by targeted magnetic heating

Abstract

Purpose. Among the different minimally invasive methods for the treatment of tumours under investigation, the accumulation of magnetic material at the target region and the exposure to an alternating magnetic field comprises a highly selective approach. In the present study, we assessed if magnetic heating of tumour cells in vitro is feasible after binding of high-affinity magnetic nanoparticles to the tumour specific protein Her-2/neu, which is known to be expressed in 30% of breast cancers.