Accuracy of repeated measurements of late‐night salivary cortisol to screen for early‐stage recurrence of <scp>C</scp>ushing's disease following pituitary surgery

Abstract

Increase in LNSC concentration is an early abnormality during post-surgical recurrence of CD. However, due to a major within-patient variability of LNSC from 1 day to another, a screening strategy using three or four samples collected on successive days may be recommended to detect early-stage recurrence of CD with a high accuracy.