Journal of Liquid Chromatography · 1980 · 13 citations · 2 references
MedicinePharmacokineticsPharmacologyBiochemical PharmacologyClinical PharmacologyNeuropharmacologyCholinergic NeurochemistryCholinergic PharmacologyDrug DispositionEnzyme InhibitionAbsorbance SpectroscopyAcetylcholinesterase FunctionAcetylcholinesterase InhibitorsAnticholinergic DrugsButyrylcholinesterase InhibitionCholinesterase Inhibitor PharmacokineticsQuantitative Determination
Abstract The potent acetylcholinesterase and butyrylcholinesterase inhibitor tetrahydroaminoacridine (THA) has been used to reverse the signs and symptoms of the acute anticholinergic syndrome in man and other animals. In order to study the pharmacokinetics of THA and related drugs we have developed an HPLC analytical method based on UV absorbance at 240 nm in TEAP buffer which permits quantitative determination in the ng/ml range in biological samples.
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Psychotomimetics as anticholinergic agents—I
Saul Maayani, Harel Weinstein, N. BEN-ZVI et al. · Biochemical Pharmacology · 1974 · 142 citations
Pheniramine Aminosalicylate Overdosage
George Mendelson · Archives of Neurology · 1977 · 18 citations