Organic Letters · 2010 · 23 citations · 15 references
Life SciencesBiochemistryMicrobiologyMetabolismMicrobial MetabolismMycologyBiotransformation PathwaysFungal Secondary MetabolitesMetabolite IdentificationMicrobial BiotransformationMicrobial Natural Product BiosynthesisSecondary Metabolite BiosynthesisBiotransformation Product IdentificationFungal Metabolite BiosynthesisFungal Terpenoid BiosynthesisMicrobial Steroid TransformationMultidimensional Nmr SpectroscopyStructure Elucidation Of Fungal MetabolitesTerpene BiotransformationTriterpene Biosynthesis
The microbial transformation of cycloastragenol by the fungus Cunninghamella blakesleeana NRRL 1369 was investigated. Unlike the original compound, the metabolite was found to possess an interesting triterpenic skeleton derived via an exceptional transformation involving ring cleavage and methyl group migration. The structure of the new metabolite was elucidated by 1-D ((1)H, (13)C) and 2-D NMR (COSY, HMBC, HMQC, NOESY) techniques and MS analyses.
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Microbial conversion of steroid compounds: recent developments
Pedro Fernandes, Alexandra Cruz, B. Angelova et al. · Enzyme and Microbial Technology · 2003 · 546 citations
Effects of triterpene saponins from Astragalus species on in vitro cytokine release
Erdem Yeşilada, Erdal Bedi̇r, İhsan Çalış et al. · Journal of Ethnopharmacology · 2004 · 179 citations
Life Sciences, Botany, Pharmacology +12