DIORGANOSILICON(IV) COMPLEXES OF FLUORO-IMINES: SYNTHETIC, SPECTROSCOPIC AND BIOLOGICAL ASPECTS

Abstract

Abstract The synthetic, spectroscopic and biological studies of some diorganosilicon(IV) complexes derived from fluoroimines having NS and NO donor systems have been undertaken. The fluoroimines were prepared by the condensation of 2-Fluorobenzaldehyde and 1-(2-Fluorophenyl)-ethanone with hydrazinecarbothioamide and hydrazinecarboxamide. These imines, on interaction with diorganosilicon(IV) chlorides, yield complexes having Si—S/Si—O and Si→N bonds. The structures of these compounds have been elucidated by microestimations and spectral [(UV), (IR), (proton-1, carbon-13, fluorine-19 and silicon-29 NMR)] studies which unerringly point to a trigonal bipyramidal and octahedral geometries for unimolar and bimolar reactions, respectively, around silicon(IV), as the active lone pair of nitrogen is also included in the coordination sphere. Studies were conducted to assess the comparative growth inhibiting potential of the synthesized complexes against the fluoroimines for a variety of fungal and bacterial strains. The studies demonstrate that the concentrations reached levels which are sufficient to inhibit and kill the pathogens. The results of biological studies have also been compared with the conventional standards, Bavistin and Streptomycin, taken for antifungal and antibacterial activities, respectively.