Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine

Abstract

Of mice and men: A vaccine composed of the fully synthetic globo H human breast tumor antigen 1 and a carrier protein elicits the formation of IgM antibodies in mice. These antibodies bind to MCF-7 breast cancer cells and trigger effective complement-mediated cell lysis. These promising results from the immune system of the mouse prompts a strategy to foster active immunity in humans.