Positive phase II study in the treatment of advanced malignant melanoma with fotemustine

Thioredoxin and Glutaredoxin Systems

Arne Holmgren · Journal of Biological Chemistry · 1989 · 1.8K citations · Full text

Microbial Toxin, Biochemistry, Glutaredoxin Systems +2

The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase

Karin U. Schallreuter, Florence K. Gleason, John M. Wood · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 1990 · 121 citations

Reductive Stress, Biochemistry, Nitrosourea Anti-tumor Drugs +9

Phase I clinical study of the new amino acid-linked nitrosourea, S 10036, administered on a weekly schedule.

D. Khayat, François Lokiec, Jean-Pierre Bizzari et al. · PubMed · 1987 · 54 citations

Weekly Schedule, Oncology, Reactive Nitrogen Specie +13

Effects of the new nitrosourea derivative, fotemustine, on the glutathione reductase activity in rat tissues in vivo and in isolated rat hepatocytes

Jean A. Boutin, Kajsa Norbeck, Peter Moldéus et al. · European Journal of Cancer and Clinical Oncology · 1989 · 17 citations

Glutathione Reductase Activity, Biochemistry, Isolated Rat Hepatocytes +14

Sensitivity and resistance in human metastatic melanoma to the new chloroethylnitrosourea anti-tumor drug Fotemustine

Karin U. Schallreuter, J.M. Wood · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 1991 · 15 citations

Oncology, Medicine, Melanoma +7