Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

Marinos C. Dalakas, Isabel Illa, G. Pezeshkpour et al. · New England Journal of Medicine · 1990 · 848 citations · Full text

Medicine, Infectious Diseases, Pathology +13

Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B

Robin McKenzie, Michael Fried, Richard Sallie et al. · New England Journal of Medicine · 1995 · 614 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.

Carlos T. Moraes, Sara Shanske, Hans Tritschler et al. · PubMed · 1991 · 590 citations

Life Sciences, Genetics, Molecular Genetics +16

Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals

JH Darbyshire · The Lancet · 1996 · 515 citations

Pharmacy, Pharmacology, Pharmacotherapy +14

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

E. Arnaudo, Sarah Shanske, S. DiMauro et al. · The Lancet · 1991 · 505 citations

Life Sciences, Infectious Diseases, Molecular Biology +17