Manual of Clinical Microbiology, 8th Edition

Abstract

A previous resection from the same site showed a schwannoma with no evidence of malignancy, and similar benign areas are present in the current biopsy.This supports our assumption that this malignant tumour has arisen by transformation from the previous lesion.An issue with this case is the history of previous radiation.It has been reported that irradiation may induce neurofibrosarcoma. 5These cases report malig- nancy arising within previously normal nerves and do not describe the induction of malignancy within a previously benign tumour.Regardless of this possible aetiology, we believe that this case represents malignant transformation within a previously benign vestibular schwannoma, and therefore presents a rare case.