Proceedings of the National Academy of Sciences · 1971 · 2.3K citations · 17 references
Life SciencesEntomologyGeneticsCircadian RhythmsGene RegulationInsect GeneticsCircadian Activity PatternsCircadian Clock MechanismsCircadian Gene ExpressionCircadian Molecular MechanismsCircadian PhysiologyMolecular ClocksBiological ClocksCircadian Locomotor ActivityCircadian Regulation Of Gene ExpressionClock MechanismClock-controlled GenesDevelopmental ClocksLocomotor Activity PatternsMolecular Clock Mechanisms
Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.
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