A Convenient Synthesis of α-Bromophenylacetic Acid from Benzaldehyde Using Methyl (Methylthio) methyl Sulfoxide

Abstract

Abstract 1-Methylsulfmyl-1-(methylthio)-2-phenylethylene (2a) and 1-methylsulfinyl-1-(methylthio)-2-(p-chlorophenyl)ethylene (2b) reacted with bromine in various solvents to give α-bromophenylacetic acid derivatives. It should be noted that α-bromophenylacetic acid and α-bromo(p-chlorophenyl) acetic acid were mainly obtained by the reaction of bromine with 2a and 2b, respectively, in acetic acid.